As our understanding of aging deepens, replacement-based strategies are emerging as a promising frontier for restoring function in aged organisms. This session explores how the deliberate substitution of aged cells, tissues, and entire organs can overcome the limitations of damage repair, offering a path toward durable and systemic rejuvenation.
Drawing on advances in stem cell biology, regenerative medicine, organ engineering, and systemic reprogramming, replacement interventions range from hematopoietic and immune system renewal to the development of functional bioprinted organs and the restoration of neuroregenerative capacity. These approaches aim not simply to patch what is broken, but to rebuild aging systems with biologically young (or synthetically equivalent), high-fidelity components.

The session brings together leading researchers who are redefining what is technically and biologically possible—from generating transplantable tissues from first developmental principles, to engineering scaffold-free organs, to uncovering how systemic signals and evolutionary insights can guide integration and long-term function.
Building on the recent Nature Aging perspective, "Replacement as an Aging Intervention," this session explores how replacement strategies can become a core pillar of therapeutic aging interventions. Moving beyond the goal of slowing decline, we will examine how targeted biological renewal offers a path to restore lost function and resilience by design—framing aging as a process that can be systematically reversed.