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Saturday, February 20, 2016

Antibody provide a more exact Alzheimer's diagnosis radioactive tracers

UPPSALA UNIVERSITY


For the first time, researchers have succeeded in passing an antibody through the blood-brain barrier to act as a tracer for PET imaging of the brain, resulting in more precise information being obtained than with regular radioactive tracers. The study provides hope for more effective diagnosis of early onset Alzheimer's disease and improvements in monitoring the effects of medication.
"The major advantage of monoclonal antibodies compared to regular small molecule PET tracers is their very high specificity. Our antibody binds soluble forms of amyloid beta, so-called protofibrils, which are probably the toxic form of amyloid and which cause the symptoms," says Lars Lannfelt, professor of Geriatrics at Uppsala University.
Positron emission tomography (PET) as a method for diagnosing Alzheimer's disease has made rapid progress in recent years. The person being examined is administered with a radioactive tracer, most often via a blood vessel. Using the PET scanner, it is possible to see how the tracer is taken up by and distributed within cells or organs.
The new PET method has been developed by researchers working at the PET Centre at Uppsala University and Uppsala University Hospital. This is the first time that a monoclonal antibody has been used for PET imaging of molecules in the brain. Such antibodies are sometimes used as tracers. In the brain, however, the uptake of antibodies is limited by the blood-brain barrier. In order to get through this, researchers have developed a fusion protein which increases the passage by a factor of about 15. The antibody is administered to the brain via another antibody which deceives a receptor on the vessel wall. The study has been carried out using live transgenic Alzheimer mice.
The researchers are currently working on a similar PET method for Parkinson's disease, it is expected that it will be possible to examine other brain conditions using these techniques, for example, depression and bipolar disorder.
Keywords: Alzheimers; Brain scans; Diagnosis.
Complete article can be read at http://www.eurekalert.org/pub_releases/2016-02/uu-apa021816.php

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