Evidence suggests there is a probable effect of exercise on the telomere length. Hence a very detailed statistical review was conducted which was aimed to assess the effects of exercise on telomere length. The following databases were closely observed: MEDLINE, EMBASE, Scopus, Cochrane Central Register of Controlled Trials, LILACS and Web of Science. All the articles that assessed the effects of exercise in telomere length were included in this review. Thirty-seven original studies were included in this review, comprising of almost 41,000 participants. Twenty articles did not show any valid association and only 15 described a positive relation. It was shown that there is a tendency toward demonstrating the effects of exercise on the length of telomeres. Few studies were found, many studies did not reach statistical importance and there was diversity in the final result. Hence, a possible significant association between physical activity and telomere length is still questionable.
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Corresponding author at: Pontifícia Universidade Católica do Rio Grande do Sul, Instituto de Pesquisas Biomédicas (IPB).